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Theory and practice of turning R & D results into productive force in major equipment

Zhang Xiaolu

Strategic Study of CAE 2011, Volume 13, Issue 8,   Pages 50-54

Abstract: companies, this paper expounds on the theoretical analysis and organizational methods of turning R & D resultsFaced with the widespread problem that putting R & D results into application is both lengthy andresponsibility and research institutes providing support," and explores the mode to promote R & D resultsThe problems in the ownership of research results, reward application and result ratification were analyzed

Keywords： R & D     major equipment     joint work of industry， college and research institute     transformation of results    

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Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 903-912 doi: 10.1007/s11684-021-0871-4

Abstract: A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia (Hhcy) and its influencing factors in China. A standardized questionnaire was used to collect information. Hhcy was defined as the level of serum homocysteine (HCY) ≥15.0 µmol/L. The H-type hypertension (HHYP) was defined as hypertension with an elevated serum HCY (≥15.0 µmol/L). Finally, 110 551 residents ≥40 years of age from 31 provinces in the mainland of China were included. Overall, the median serum HCY level was 10.9 µmol/L (interquartile range 7.9–15.1). A total of 28 633 participants (25.9%) were defined as Hhcy. The Hhcy prevalence ranged from 7.9% in Shanghai to 56.8% in Tianjin. The data showed that serum HCY levels were associated with age, male gender, cigarette smoking, hypertension, diabetes, ethnicity, endurance in exercise (inverse), and fruit and vegetable intake (inverse). In addition, 15 486 participants were defined as HHYP, and the rate was 14.0%. HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752 (95% CI 1.338–2.105). The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences, and national strategies should be carried out to further improve the care of patients with Hhcy across China.

Keywords： homocysteine     hyperhomocysteinemia     H-type hypertension     Chinese    

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Joint slip investigation based on finite element modelling verified by experimental results on wind turbine

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 341-351 doi: 10.1007/s11709-017-0393-y

Abstract: study, 8 different types of joints are modelled and studied in the finite element program, and the resultsare verified by the experimental results which have been done in the laboratory.

Keywords： Joint slip     cyclic loading     Finite element modelling     Experimental joint behavior     damping ratios (   

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Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 470-474 doi: 10.1007/s11684-009-0077-7

Abstract: The aim of this paper was to observe the clinical effect of gentamycin combined with sodium bicarbonate for the prevention of irinotecan-induced diarrhea. A total of 98 patients with stage IV cancers were recruited and divided into a prevention group (52 patients) and a control group (46 patients). All patients received the chemotherapy including irinotecan. The prevention group received gentamycin and sodium bicarbonate before the use of irinotecan for 4 days; the control group did not receive any prevention. The use of gentamycin and sodium bicarbonate resulted in significantly higher stool pH ( < 0.001), while the incidence of diarrhea by irinotecan was reduced (prevention group 13.70% control group 34.83%; < 0.001). Gentamycin combined with sodium bicarbonate appears to be useful in preventing the diarrhea induced by irinotecan and reducing the dosage of loperamide and fluid replacement.

Keywords： irinotecan     diarrhea     gentamycin     sodium bicarbonate     prevention    

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improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis. Patients were recruited from prospective skin cancer centers and the German national skin cancer registry (ADOReg) of the German Dermatologic Cooperative Oncology Group (DeCOG). Two cohorts were compared: patients with LDT (cohort A, n = 78) versus those without LDT (cohort B, n = 104). Data were analyzed for response to treatment, progression-free survival (PFS), and overall survival (OS). The median OS was significantly longer in cohort A than in cohort B (20.1 vs. 13.8 months; P = 0.0016) and a trend towards improved PFS was observed for cohort A (3.0 vs. 2.5 months; P = 0.054). The objective response rate to any ICB (16.7% vs. 3.8%, P = 0.0073) and combined ICB (14.1% vs. 4.5%, P = 0.017) was more favorable in cohort A. Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM.

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Transformation of triclosan by a novel cold-adapted laccase from

Yuanyuan Shi, Deyang Kong, Jiayang Liu, Junhe Lu, Xiaoming Yin, Quansuo Zhou

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 3, doi: 10.1007/s11783-017-0927-5

Abstract: This work investigated the transformation of triclosan (TCS) by laccase produced by a pathogen isolatedTransformation products of TCS were analyzed by mass spectrometry and it was revealed that TCS dimerswidely presented in natural environment, this study also revealed an important pathway involved in the transformation

Keywords： Laccase     Botrytis cinerea     Triclosan     Transformation     Kinetics    

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FOOD SYSTEMS TRANSFORMATION: CONCEPTS, MECHANISMS AND PRACTICES

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 1,   Pages 1-3 doi: 10.15302/J-FASE-2023491

Abstract: FOOD SYSTEMS TRANSFORMATION: CONCEPTS, MECHANISMS AND PRACTICES

Keywords： TRANSFORMATION     SYSTEMS     FOOD     CONCEPTS     MECHANISMS    

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TRANSFORMATION OF FOOD SYSTEMS: HOW CAN IT BE FINANCED?

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 1,   Pages 109-123 doi: 10.15302/J-FASE-2023483

Abstract:

● The analysis of financing for the transformation of food systems

Keywords： financial markets     food systems     development financing     consumer expenditures     public budgets     Sustainable Development Goals    

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The transformation of PAHs in the sewage sludge incineration treatment

Hui ZHANG,Le XU,Yifei ZHANG,Mengchan JIANG

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 2,   Pages 336-340 doi: 10.1007/s11783-014-0766-6

Abstract: The result indicates that the transformation may occurre between monomers of PAHs during their releaseThe possible transformation of Naphthalene to indeno(1, 2, 3-cd)pyrene was related to the temperatureHere, we showed that the output rate of transformation reactions for indeno(1, 2, 3-cd)pyrene is 94%

Keywords： release of monomers     transformation of monomers     PAHs     sewage sludge     incineration treatment    

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Strategic Updating of Internet Plus Considering Digital Transformation

He Wei,Zhang Weidong,Wang Chaoxian

Strategic Study of CAE 2020, Volume 22, Issue 4,   Pages 10-17 doi: 10.15302/J-SSCAE-2020.04.002

Abstract: These necessitate the construction of a new system and exploration of new paths for the transformationhave gradually improved, a new blueprint for the transformation has emerged, and the integration ofHowever, the digital transformation framework system needs to be reconstructed, the key elements of transformationecology, establish transformation and innovation networks, and upgrade the policy support system forthe Internet Plus initiative, thereby promoting the digital transformation of economy and society to

Keywords： technology industry transformation     digital transformation     Internet Plus     industry upgrade    

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Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 67-70 doi: 10.1007/s11684-010-0023-8

Abstract: A community-based multi-center randomized controlled trial was conducted to evaluate the effectiveness of blood pressure control for hypertension patients in communities in urban Shanghai by integrated intervention. At present, patients (=1395) from four communities have completed follow-up for one year, including the intervention group (=921) and usual care group (=474). The intervention programs included disease management by a care manager. Blood pressure of each patient was measured regularly. Compared with the control group, the net change of mean systolic blood pressure (SBP) was −6.75 (95% CI: −7.79 to −5.71, <0.001) mmHg, mean diastolic blood pressure (DBP) was −4.29 (95% CI: −5.08 to −3.49, <0.001) mmHg, and mean pulse pressure (PP) was −2.46 (95% CI: −3.50 to −1.43, <0.001) mmHg in the intervention group. The net change extent was larger in patients with regular pharmacological treatment than in those with irregular pharmacological treatment or non-pharmacological treatment. The measures of integrated intervention for hypertension patients in communities can lower significantly not only SBP and DBP, but also PP. It is suggested that measures of integrated intervention can decrease the risk of cardiovascular diseases in hypertension patients.

Keywords： hypertension     community     pharmacological adherence     control of blood pressure    

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Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 101-107 doi: 10.1007/s11684-020-0752-2

Abstract: Primary hypothyroidism commonly occurs after radiotherapy (RT), and coincides with increased circulating thyroid-stimulating hormone (TSH) levels. We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma (HL) in a prospective cohort study. From 1998 to 2001, a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL, scheduled for craniospinal irradiation and mediastinum/neck radiotherapy, respectively, underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of craniospinal iiradiation. From 14 days before and up to the end of radiotherapy, patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3 μIU/mL. During follow-up, blood tests and ultrasound were repeated; primary hypothyroidism was considered an increased TSH level greater than normal range. Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels ˂ 0.3 μIU/mL and well matched for other variables. Twenty years on, hypothyroidism-free survival rates differed significantly, being 60%±15% and 15.6%±8.2% in TSH-suppressed vs. not-TSH suppressed patients, respectively ( =0.001). These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae, but it should be confirmed in a larger cohort.

Keywords： iatrogenic primary hypothyroidism     late effects of radiotherapy     long-term follow-up     medulloblastoma     Hodgkin lymphoma    

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Crystal-to-crystal transformation from the triclinic to the cubic crystal system by partial desolvation

Qianqian Guo, Irmgard Kalf, Ulli Englert

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 433-439 doi: 10.1007/s11705-018-1743-6

Abstract: The transformation reaction proceeds via dissolution and recrystallization.

Keywords： ditopic ligand     substituted acetylacetone     desolvation     diffraction    

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Polymorphism and crystal transformation of penicillin sulfoxide

Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 4,   Pages 442-447 doi: 10.1007/s11705-011-1140-x

Abstract: Furthermore, the transformation of form II to form I was studied quantitatively by Raman spectroscopyThe results indicate that penicillin sulfoxide is more stable as form I, and the temperature plays animportant role in the crystal transformation.

Keywords： penicillin sulfoxide     crystallization     polymorphism     crystal transformation     Raman spectroscopy    

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A comprehensive simulation approach for pollutant bio-transformation in the gravity sewer

Nan Zhao, Huu Hao Ngo, Yuyou Li, Xiaochang Wang, Lei Yang, Pengkang Jin, Guangxi Sun

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1144-1

Abstract:

A comprehensive pollutant transformation model for sewer systems

Pollutant transformation is attributed to different

Keywords： Gravity sewer     Modeling     Pollutant transformation     Biochemical reaction process    

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Title Author Date Type Operation

Theory and practice of turning R & D results into productive force in major equipment

Zhang Xiaolu

Journal Article

Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

Journal Article

Joint slip investigation based on finite element modelling verified by experimental results on wind turbine

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Journal Article

Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

Journal Article

improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results

Journal Article

Transformation of triclosan by a novel cold-adapted laccase from

Yuanyuan Shi, Deyang Kong, Jiayang Liu, Junhe Lu, Xiaoming Yin, Quansuo Zhou

Journal Article

FOOD SYSTEMS TRANSFORMATION: CONCEPTS, MECHANISMS AND PRACTICES

Journal Article

TRANSFORMATION OF FOOD SYSTEMS: HOW CAN IT BE FINANCED?

Journal Article

The transformation of PAHs in the sewage sludge incineration treatment

Hui ZHANG,Le XU,Yifei ZHANG,Mengchan JIANG

Journal Article

Strategic Updating of Internet Plus Considering Digital Transformation

He Wei,Zhang Weidong,Wang Chaoxian

Journal Article

Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

Journal Article

Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

Journal Article

Crystal-to-crystal transformation from the triclinic to the cubic crystal system by partial desolvation

Qianqian Guo, Irmgard Kalf, Ulli Englert

Journal Article

Polymorphism and crystal transformation of penicillin sulfoxide

Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG

Journal Article

A comprehensive simulation approach for pollutant bio-transformation in the gravity sewer

Nan Zhao, Huu Hao Ngo, Yuyou Li, Xiaochang Wang, Lei Yang, Pengkang Jin, Guangxi Sun

Journal Article